Amicus Therapeutics for a Better Life With Rare Diseases

Rare and orphaned diseases can sometimes fall off the radar of public thought, with by its very definition less than 200,000 people or about 1 in 1,500 have to suffer from these diseases for them to be classified as such in the United States. This leads to less funding being invested in researching cures and treatment, and a smaller pool from which to pull in research patients (http://www.marketwatch.com/investing/stock/fold). Amicus Therapeutics, however, believes that investing and creating treatments for these rare and orphaned diseases is not only vital to those suffering from them but to understanding and treating common diseases as well.

 

Amicus Therapeutics largely uses the Chaperone-Advanced Replacement Therapy or CHART platform. Concentrating on enzyme replacement therapies or ERTs, Amicus Therapeutics has become a biotechnology leader in research and development for rare diseases in the pharmaceutical industry. Currently, the lead candidate is migalastat (trade name Galafold), a chaperone treatment platform for Fabry Disease that hopes to stabilize the mutant gene that causes the condition. Additionally, Amicus Therapeutics has treatment research ongoing for Pompe disease, and other Lysosomal Storage Disorders (LSDs). Pompe disease treatment is being led with biologics program, ATB200/AT2221, which is making great steps in treating the genetic disorder.

 

Amicus Therapeutics is devoted to patient advocacy as well, supporting and empowering those with these disorders and their families to ease the difficulties they face. Learning by listening to the patients earnestly. Using this input to use in the design of clinical trials for therapies and research allows better advances in the drug development and new therapy processes (Dialdish). Feedback on what patients actually are facing daily provides the opportunity to get advice on the both the needs and what improves their quality of life. This helps in not only treatment options but for Amicus Therapeutics to educate, support, and advocate on behalf of patients in the public space as well.

Osteo Relief Institute: Battles Arthritis

Osteo Relief Institute is a center that provides non-invasive treatment options for Knee Osteoarthritis. Osteoarthritis is a common type of arthritis which is also known as degenerative joint disease. The condition leads to the gradual destruction of the soft tissue which is found between joints.

 

Arthritis affects over 50 million people in America. There are over 100 variants of the disease which refers to a joint disease or joint paint. The disease mostly affects women and older adults. The joint condition is one of the leading causes of disability cases in America (ChronicalWeek). Arthritis has no cure, but the chronic pain associated with it is manageable. As we age bone, cartilage wears away and breaks down. Eventually, your bones are bound to rub against each other, and this will cause stiffness, pain, and swelling. When this happens, chronic pain is associated with all your joints.

 

However, osteoarthritis has some risk factors which you can look out for and protect yourself. Some of these risk factors include age, excess weight, previous injuries, and family history. Once you start feeling the symptoms of Osteoarthritis, you must act swiftly to minimize the severe effects that come with the disease. Acting swiftly reduces the effects of the degeneration and extent of the pain. Some measures have been discovered to help you follow to minimize the pain of Osteoarthritis and its extent. Some of them include;

  • Mild exercises that may include stretching, movement exercises, and strength training. You may also do aerobics. Walking, water exercise and cycling also helps to keep you mobile and to control your weight and in improving your general mood.

 

  • Don’t forget to make sure that you move every day. The physical movement even if it’s mild helps to control the pain.

 

  • Avoid repeating the same procedure like playing golf, jumping or tennis. This tends to stress specific joints, thereby making arthritis worse.

 

About Osteo Relief Institute

 

Osteo Relief Institute focuses on the non-invasive treatment of Osteoarthritis. The Institutes employ professional medics who can handle the condition expertly. The Institute’s board has physical therapists and physicians that are competent and have been board certified. Osteo Relief Institute uses the most advanced methods to produce the best methods of handling any chronic pain that is associated with Osteoarthritis. The main aim of the establishment is to provide safe and efficient treatment to manage Osteoarthritis (http://alivenewspaper.com/2017/09/osteo-relief-institue/).

 

ELI GERSHKOVITCH: SPREADING THE POPULARITY OF CRAFT BEER THROUGH STEAMWORKS

Eli Gershkovitch And Canadian Craft Beer

 

After Prohibition swept through Canada, many breweries and beers became available. Some of these breweries and beers are still around today, and some newer breweries and beers have touched the soul of all Canadians, including visitors.

 

One of the most popular beers today is the Lake Lager. This beer is provided by the Brick Brewing Company. What makes Lake Lager different from all other beers is that it is distributed colder than all other beers in Canada. Additionally, Lake Lager comes with no aftertaste at all, and Lake Lager has been brewed in a way that it does not bloat the stomach. The working-class of Canada craves this beer on a daily basis.

 

Another great Canadian craft beer is All Or Nothing, which is brewed by the All Or Nothing Brewhouse. People in Canada rave about this beer because of its aroma. As soon as the bottle is opened, the atmosphere is filled with scents of bubblegum and banana. The beer itself sparkles like diamonds, and it has a rich gold color to it. The taste of this beer is equivalent to watermelon and strawberries. There is even evidence that this beer promotes an energetic lifestyle. People in Canada love drinking this beer during the summer and while watching sports.

 

An additional fantastic Canadian craft beer is Ambear Red Ale, and it is brewed by Cameron’s Brewing Company. Ambear Red Ale has won several awards for being voted the best beer in Canada. It takes its name from its red wine color. This beer is special because of how the flavor changes with each sip. The first few sips will taste like citrus, and the next few sips will have a sweet vegetable taste to it. This beer is also known for promoting a happy attitude. Canadians always choose this beer when they are dining or eating fast food.

 

The most famous brewery of all is the Steamworks Brewery, which is run by Eli Gershkovitch. Eli Gershkovitch began Steamworks Brewery in the early 90’s. It was discovered that several old pipes existed underground. Eli Gershkovitch had the idea to build a brewery run solely by steam (Manta). Several architects and construction companies were able to make this a reality.

 

Steamworks Brewery is known for making potent beer due to the immediate delivery of steam (https://www.manta.com/ic/mtqs8v5/ca/gershkovitch-eli-a-law-corporation). Steamworks Brewery is known to Canadians as a freestyle brewery because you never know what type of beer you will find when you enter the brewery. They may have their famous Pale Ale available, or they may have their famous Cucumber Ale. They also custom make beer right on the spot.

 

Before opening a brewery, Eli Gershkovitch was a pilot while attending law school. During law school, Eli Gershkovitch always went for a drink with friends. However, Eli Gershkovitch was looking for something more than beers from traditional breweries. Hearing about the possibility of powering a brewery on steam was a dream come true for Eli Gershkovitch. He knew he could serve beer that was abnormal but that would become normal, and even award-winning, in a short period of time.

 

The Secret behind Edisoft

Edisoft is mainly involved in ERP integrated Electronic Data Interchange and ERP integrated Warehouse and Shipping automation. What has been key to Edisoft recent success is invention and innovation. Edisoft has been able to incorporate new and exciting products and services that have made it easier for suppliers to fulfil orders from international online web stores such as Wal-mart.com. Currently, Edisoft is one of the leading North America’s Supply Chain Software Companies. As it stands, Edisoft objectives only prove that 2017 is going to be another booming year. Edisoft is seeking self-motivated success driven young youths to add to its already established results driven culturally diverse team (Crunchbase). Edisoft had its roots back in 1995.

 

Its sole objective of being founded was to provide EDI solutions to both small and medium sized firms thus making it easier for them to connect with their trading partners. Initially, it seemed like an unachievable goal. However, as the adage says success does not come on a silver platter, and every mighty run starts with a single stride. Initially, Edisoft assembled a team of an international team Edi and software experts in Toronto which was its headquarters by then. The team then ventured on an intensive R&D program that would later lead to the unveiling of an Edisoft Merchant suite of products and a refined EDI solution that would blend in with most native databases of major accounting systems. Initially, when visibility solutions were first made available, measuring on-time performances was the most vital indicator for the transportation department (http://www.bloomberg.com/research/stocks/private/snapshot.asp?privcapid=9478384). However, motor carriers used their service types to be measured.

Both ocean and air carriers used on-time measure modes. Uses of multimode or multi-leg shipments were very scarce occasions. In the current market, when it comes down to the evaluation of opportunities for supply chain performances, the best practice KPI’s now do not focus on individual operations of a particular carrier instead they focus on metrics across trading partners. The main key to properly analyzing and obtaining desired conclusions from big data is ensuring all the parties involved give complete, true and timely data. It is also important to have an evaluation criterion and an appropriate data quality management program.

 

Glen Wakeman Is A Charitable Man

Glen Wakeman has been a man of charity all of his life. This began in college, where he started many fundraisers to help local businesses in the area. He did this in both Scranton, P.A. and in Chicago. Even his fundraisers were put together to help people read or learn financing or some other important factor.

After graduating, Glen Wakeman continued his heart for charity. He accomplished this by doing more than his salary offered him. Essentially, he worked for free to help manage businesses and get their finances in order. This warranted Glen Wakeman a list of awards that he credits to his family and mentors who instilled great values in him over the years.

Now, Glen Wakeman owns LaunchPad Holdings. This company assists businesses with managing their money and investments. LaunchPad Holding receives a new client practically every single day. Glen Wakeman has also invested his charitable heart into this company. Glen helps many local businesses for free. He selects several businesses from the local area and surrounding areas each month. Voluntarily, his team and himself assist these businesses with getting back on track.

LaunchPad Holdings is even responsible for helping nonprofit organizations in their local area and around the world. Every month, Glen Wakeman writes checks to help nonprofit organizations. To date, LaunchPad Holdings is responsible for distributing over 5 million dollars to not-for-profit organizations. However, Glen Wakeman does not stop there. Glen helps these not-for-profit organizations by going through their budget and cutting away anything that is holding the organization back. Glen also has a team of grant writers who write letters for nonprofit organizations on a monthly basis. These letters are mostly to the government (https://www.facebook.com/glen.wakeman). This is done so these organizations receive more help from the government than what is traditionally given on an annual basis.

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Quality Air Conditioning Services-Goettl Air Conditioning

Walton Heating and Air is an HVAC Company which have its operational offices in Southern California. Recently another ancient air conditioning company Goettl Air Conditioning announced the acquisition of Walton heating and Air which is also a family firm. The deal is an advantage to both air conditioning service providers; Goettl that mainly delivers its services to Phoenix, Las Vegas, as well as Tucson will have an opportunity to expand to Southern California while Walton heating and Air will do more than it could have done on its own. According to Todd Longbrake who is the founder of Walton Heating and Air, the firm’s management had done all it could to move forward but it got stuck.

According to PR News Wire, Goettl showed interest in the purchase of Walton in 2015 a request that was not well with the founder Mr. Todd. Nevertheless after a while and getting adequate and satisfying promises from other HVAC firms about Goettl and its founder Goodrich; Todd decided to sign the deal. Mr. Todd is happy with the results that have come long after their joining together. He said that the air conditioning firm has expanded 10 times than before. Mr. Todd Longbrake who is the owner of Walton Heating and Air Company is the current sales manager as well as the field supervisor a position that he has retained. Goodrich was quoted saying that Todd has adapted into the Goettl’s team so well and has become part of the management. The two companies have almost the same family values and back ground, and their coming together to do business is to make Goettl Air Condition expand. The company is planning to expand their services to Texas in 2018. Visit Azcentral for more.

Goettl Air Condition Company is built on a strong mission to do the right thing to their clients from the first day as they offer unrivaled quality services. The air conditioning organization is a family business firm which was established in 1926. Ever since their inception; the firm has remained to be one of the top air conditioning companies in Phoenix, Arizona region. Despite Goettl being an ancient company; it has been able to evolve with technology and rise above deliver quality services and products. As a leader in the air conditioning company; Goettl has been in the front line to improve and offer tailor made services to their clients. Some of the services and products which the old air conditioning and the heating firm provides include; maintenance, repair, installation, as well as heating and cooling services.

See more: https://www.crunchbase.com/organization/goettl-air-conditioning-2#/entity

Aloha Construction Services, the Best a Home can Get

Aloha Restoration Company takes pride in its restoration home remedies. It transforms houses to homes through its remarkable services it offers its clients. This is quite evident through their slogan “Your dream home in no time.”
Through licensing of its staff and equipment, it guarantees clients top professional service delivery. This includes both minor and major renovations of bathrooms and unused/old basements. Their pocket-friendly and free property/Home assessment makes them unique.
Mold invasion solutions are also available. They go a step further to determine the cause. This is through carrying out mold evaluation and reinstatement. Their services are reliable and certified by the International Restoration Institute hence no residual effect. Fire damage and animal/cigarette odor solutions are offered through their certified technology by the Institute of Inspection, Cleaning, and Repair.
About Aloha Construction
Based in Lake Zurich, Aloha Construction Inc is a name that brings hope to various residents with home construction related issues. With an extensive branch focusing on the reinstatement of interior and home makeover, It is a genuine relief to numerous residents and businesses. Their services are performed with their highly qualified staff of experts. This includes various home related fields such as complete interior remodeling, water, and fire damage reinstatement, removal of the mold to carpet cleaning.
Formerly known as local roofing and siding contractors, Aloha Construction Inc has become diverse through launching Aloha Restoration Co. The new company focuses on mold, fire, water and home restoration issues. With the main aim being service delivery, the companies’ aim is to offer satisfactory quality service to their clients by improving their homes. This is why the company is always targeting to get the best training of its staff to achieve excellence through certification and licensing.
In response to the emergency occurrence, Aloha has partnered with various local authorities that are closer to its clients. This is through their 24-hour working strategy with swiftness in emergency response. This reduces clients hustle as it offers a free in-home assessment. ”Your Dream Home in No Time.” slogan places Aloha Construction as a true answer to home restoration.

Life of Dr. Scott Rocklage

Scott Rocklage, started working for 5AM Ventures in 2003. He started off as a venture partner. A year later he rose to the position Managing Partner in the same organization. Dr. Rocklage has held various positions in his careers.

These include: Chairman and CEO of Cubist Pharmaceuticals, President of Nycomed Interventional President and CEO of Nycomed Salutar. Dr. Rocklage holds a B.S. in Chemistry from the “University of California, Berkeley,” and a Ph.D. in Chemistry from the “Massachusetts Institute of Technology.” Read more: Scott Racklage | Bloomberg and Scott Racklage | Crunchbase

Dr. Scott Rocklage has been an inspiration to many people in the field of biochemical research and entrepreneurship. Rocklage who is based in Boston has a vast knowledge of healthcare management, which is a field he has served for about 30 years.

This experience coupled with a background in scientific research and leadership roles makes him an effective leader in the field pharmaceuticals, health care, and venture capital.

From this vast educational and work experience, Dr. Rocklage has seen three drug applications approved by the FDA under his name. He has also been credited with entering 6 other candidates into clinical tests. He has directly or indirectly invented 30 Patents in the United States. Also under his name are over 100 publications.

5AM Company engages in the formation of companies. As the name 5am, it indicates formation at an early stage. Rocklage roles at 5AM involve maintaining the portfolio of the company and studying emerging facets of life science. He works closely with other entrepreneurs serving in the area of life science.

They will include people such as business executives, physicians, and scientists. With such people, they come up with new drugs that address issues in the field of medicine.

Dr. Scott Rocklage has steered 5AM Ventures to great achievements and has attracted clients from far and wide. Dr. Rocklage encourages the use of modern techniques in diagnosing and treating medical problems.

Rick Smith the Big Name behind Securus Technologies

It is without a doubt that you know Securus Technologies for the giant it is in the correctional industry; not because you have an incarcerated loved one but for the progress it is making in the industry. Yes, this is true and the man behind this huge success is one Rick Smith, the company’s CEO since 2008. Rick influence in the industry goes beyond his company. Arguably, through his influence Securus Technologies has become the industry’s benchmark in terms of how correctional operations are conducted and in particular through the use of technology. Rick Smith’s CV is well decorated. While most people may tend to think that he had it easy on the CEO position, nothing could be further from the truth. In reality, Rick has worked himself up the ladder taking different positions such as information technology, finance and operations. These positions coupled up with his exemplary leadership skills have fueled his success and that of Securus Technologies.

Education wise, Mr. Rick Smith is well schooled. His education qualification includes an associate degree from RIT (Rochester Institute of Technology). In addition to this he has a degree in engineering from the New York state University, an MBA and a master’s in Engineering. These academic qualifications are well backed up with practical work experiences. Rick first job was in Global Crossing North America Inc. where he worked from 1972 to 1998. Here was involved in the roles of chief information officer and controller for the company. After here, Smith advanced career wise and become the president of Frontier Information technologies. He has worked at Midwest telephone operations as the vice president and also in Network plant operation where he was in charge of the business operations for the company.

It is true to say that Rick Smith big career achievement was in Eschelon Telecom Inc. During his tenure with the company Mr. Rick helped the company make huge profits growing its revenues ten folds from $30 million. As if this is not all, Mr. Rick also helped the company successfully trade it shares in the IPO market.With such a decorated CV, it is evident that Rick Smith is a man with a hearth in the incarceration industry. After joining, Securus Technologies Rick has been able to transition it from an ordinary company to one that is committed to excellence through technology. Securus Technologies currently tops the chart when it comes to the use of technology in the inmate industry. This is two way, as it is evident from the company’s customers positive review. Most of the sampled customers are of the opinion that the services offered and delivered by the company is of high quality.

Louis Chenevert, UTC, and Investing in the Future

Investing in future growth is a hallmark of the United Technologies Corporation’s (UTC) ethos, and they believe that their employees are a key element of all of their successes. In fact, beginning in 1996 and continuing to today, the UTC Employee Scholar Program has provided education to its employees at the institute of their choosing, in whatever subject they desired. To date, over 39,000 degrees have been received with over $1bn spent on the program. This program for lifelong learning is just one way that UTC values its employees and invests in their future.

In addition to these education initiatives for employees, UTC also invests in its suppliers. It is the firm belief of the company that has strong and financially healthy suppliers helps to increase the quality of UTC’s products.

A lot of this corporate culture was initially put into place by UTC’s former CEO, Louis Chenevert. This Connecticut-based company provides the assembly of jet engines and its Sikorsky division has produced more helicopters than any other American company. Formerly of GE, Louis Chenevert joined UTC’s Pratt and Whitney engine division in 1993. During his tenure, Chenevert was responsible for bringing back multiple positions from less expensive countries and had the positions based in the U.S.

As CEO, Chenevert positioned the company with both military and commercial clients as their corporate business cycles usually offset each other, and thus, UTC was able to avoid many boom and bust cycles that affected competitors with clients in only one of the sectors. Chenevert followed his instincts and was able to successfully balance a business approach that utilized both imagination and precision. This adaptive way of handling various situations allowed the company to realize profits during all segments of their product life-cycles and smooth out some of the peaks and valleys usually associated with the aerospace design and engineering industries. Following his retirement, UTC continues to approach its business in much the same way. It will be interesting to track their progress as the innovation continues.

See Chenevert speak here!