Mikhail Blagosklonny: Bringing the Miracles of Rapamycin to Medicine

Cancer is one of the most fatal diseases in the world, and it can hit anyone, regardless of nationality, gender, and social status. It is also a widespread disease, to the fear of many citizens, because it has dozens of types and each of them has different detrimental effects on one’s health.

However, according to statistics, the most affected by cancer is the poor, and it is not because there’s a higher rate of cancer in poor communities. It is because most cancer treatments are very expensive. More than that: Chances are, if you are poor and got stricken by cancer, you won’t be able to afford it. Mikhail Blagosklonny is one of the top oncologists in the world in the development of a cure for cancer, and he aims to chance that reality forever. His mission in life is to create cancer treatment methods that can be affordable for all and available in the entire world. Although the medical community agrees that it is a far-fetched goal, Mikhail Blagosklonny is proving the world wrong, as he continues to make progress in his quest to change cancer therapy.

Oncology is the field of science which studies the treatment of tumors. Mikhail Blagosklonny spent his whole life researching tumors, how to treat it, and, most specifically, find ways to treat cancers in the most efficient and yet affordable way. This comes with a couple of problems, like the availability of drugs for everyone and the detrimental effects that come from cheaper ingredients.

Throughout all the years of Mikhail Blagosklonny’s study and practice of oncology, his research on Rapamycin is his most impressive achievement. In a lot of cancer treatments, organ transplant is one of the best solutions to save the patient. The problem and risk involving organ transplant are that our immune system is designed to fight off foreign substances and the first ‘instinct’ of our immune system when it detects a transplanted organ is that it is a foreign substance, and so needs to be eliminated. Fortunately, Rapamycin is one of the drugs that can prevent this kind of rejection by the immune system.

Mikhail Blagosklonny considers Rapamycin a “wonder drug” because not only can it inhibit the immunity system rejecting organ transplants, it is also the primary drug approved and used for the treatment of Lymphangioleiomyomatosis or LAM. Using Tuberous Scleroris Complex gene mutations, LAM infiltrates the lung tissue and in effect activating the mTOR signaling gateway. Because of this, Lymphangiogenic growth factors are released, but, if treatment with Rapamycin is administered, Rapamycin would block the gateways. It is considered a wonder drug because of the many uses it can have for medicine.

Aside from being an immunosuppressive drug, Rapamycin is also one of the best anti-proliferative drugs because it prevents cancer cells from spreading in the body. Because of all the wonders, Rapamycin can bring to the world of oncology, Mikhail Blagosklonny is tirelessly researching more ways Rapamycin can be used in the treatment of cancer. He believes that once the full potential of Rapamycin is discovered, more affordable of treatments will be available to the people.

Why James Larkin stands outs as a Labor Organizer

James Larkin was a renowned labor activist who advocated for worker’s rights in the early 20th century. He had unparalleled vivacity, courage, and ideas. The activist was born to a low-income family that lived in the Liverpool’s informal settlements.

The financial state of his parents made him miss the opportunity of getting a quality education. Larkin got a casual job at the dock so that he could earn some extra money for his family. In his early twenties, he was hired him as foreman. James felt like he was being oppressed while working at the dock was inspired to become a labor activist.

He was a committee socialist who strived to end capitalism and also ensure that the rights of the less privileged people were not violated. The activist was recognized in 1905 for his participation in a dock strike, and the National Union of Dock Labourers (NUDL) appointed him to be one of its labor organizers.

Larkin was sent to Belfast in 1907 and led the first unskilled labors’ strike. He started a strong branch of the NUDL, and it was significantly opposed by employers.

The NUDL transferred Larkin to Dublin in 1908 where he was in charge of rallying port employees. He did not like the way the union treated him in Belfast, and this led to his exit from British trade unionism. James later started the famous Irish Transport and General Workers Union (ITGWU), which became the country’s most influential union in less than three years.

Most workers respected him because of his outstanding work. The activist inspired many people and dedicated himself to ensuring that all laborers had the best working conditions.

He also struggled to make sure that the workers got the respect that they deserved. Larkin supported ideas that advocated for equity and social justice. In 1911, James created the Irish Worker and People’s Advocate, a weekly newspaper that sold over 20000 copies. It was among the city’s most powerful propaganda sheets at that time. The labor organizer purchased the Liberty Hall in 1912 to become the headquarters of ITGWU. Read more: Jim Larkin | Wikipedia

The ITGWU was responsible for leading all unskilled labor activities in the capital. This excluded the building trade, Dublin United Tramway Company (DUTC), Guinness’ Brewery, and the Corporation. The infamous Dublin Lockout that occurred in 1913 was motivated by a disagreement between the DUTC and James Larkin.

Over 100,000 workers participated in the industrial action that paralyzed the dock for months. The long strike devastated his union, and he flew to the United States in 1914 to seek funds to strengthen it. James led a group of protesters to stop the U.S from taking part in World War I. After a while, he openly started showing support for the Soviet Union and also organized illegal demonstrations.

James Larkin was sent to jail in 1919 and was deported in 1923 after being pardoned. His career in the labor movement sector failed to blossom after returning to Ireland since he did not have a lot of support. The activist died in 1947.